Development and characteristics of topical gel containing nimesulide: A review

Topical drug delivery system are becoming more and more popular and thus multiple drug have been effectively administered for each local and systemic action a maximum of non-steroidal anti-inflammatory drugs (NSAIDs) in recent years to raise awareness of these drug to deliver drugs topical gel protect against gastrointestinal irritation overcome " first pass " effect and maximize their action since the gel is not sticky and require less strength throughout the composition it has a higher dosage than topical formulation when evaluating an ointment. Nimesulide is a common non-steroidal anti-inflammatory drug (NSAIDs) that is effective in relieving a wide range of pain and inflammations but is more tolerated than other NSAIDs the terminal half-life of nimesulide is about 4 hrs. it is Cox 2 inhibitor used for variety of inflammatory pain and fever state gel are cross linked polymer network that expand in a liquid medium it's properties mainly depend on the interaction of solid polymer and liquid component the gel does not spread evenly gel formulation provide an appropriate these delivery system for the drugs are less greasy and can be easily removed from the skin.