Rutin and Vitamin E alleviate oxidative stress and hepatic-renal injury induced by technical and formulated Lambda-cyhalothrin in adult rats

Lambda-cyhalothrin (LCT) is a widely used pyrethroid to control insect pests in agriculture, public health and homes. The present study was designed to assess some of the toxicological effects in male rats following exposure to technical and formulated lambda-cyhalothrin (LCT T and LCT F.) and to evaluate the ameliorative effect of Vitamin E and Rutin administration. Nine groups of rats were designated for: control group; RT (50 mg kg-1 b.wt.); Vitamin E (100 mg kg-1 b.wt.); LCT T. (20 mg kg-1 b.wt); [LCT T. +Vitamin E]; [LCT T. +Rutin]; LCT F. (20 mg a.i. kg-1 b.wt); [(LCT F.) +Vitamin E] and [(LCT F.) +Rutin]. Results revealed that both of technical and formulated lambda-cyhalothrin treatments caused significant increase in LPO level and decrease in the activities of antioxidant enzymes: catalase, superoxide dismutase, glutathione-s-transferase Glutathione peroxidase, and glutathione reductase. Also, both forms of lambda-cyhalothrin caused significant increase in the activity of alanine and aspartate transaminases and alkaline phosphatase, lactate dehydrogenase and creatinine, uric acid levels, whereas albumin, total protein were decreased. Coadministration of Vit.E or Rutin achieved noticeable ameliorative effects. Thus, the overall results revealed the powerful ameliorating effect of Vit.E and Rutin in pyrethroids (e.g.LCT)-intoxicated rats.