Green synthesis of pyranopyrazole using microwave assisted techniques

The process of drug discovery involves the identification of lead molecule, synthesis, characterization, screening, assay for therapeutic efficacy. The Pyrano[2,3-c] pyrazole are important roles in the field of pharmacological and medicinal chemistry. The pyranopyrazole are important class of hetrocyclic ring prepared by a diverse range of synthetic procedure. The water as a green solvent is most enviormentally friendly, safe and inexpensive choice to decrese pollution, toxicity and cost of reaction. The Microwave irridation to eliminate the requirement of heat, enhance the rate of reaction and decreased total time is a widely applicable techinque and has been used for the synthesis of pyranopyrazole. The synthesis prepared by pyrazolone, aldehyde and malononitrile are allowed to react together under diffrent reaction condition to form a variety of pyranopyrazoles. The Pyranopyrazoles in general are biologically active and have remarkable antimicrobial, anticancer, anti-inflammatory, analgesic, antifungal etc.