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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

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Tranexamic Acid Induced Seizure in a Nullipara with Abnormal Uterine Bleeding due to Symptomatic Uterine Fibroids. A Case Report

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  • Tranexamic Acid Induced Seizure in a Nullipara with Abnormal Uterine Bleeding due to Symptomatic Uterine Fibroids. A Case Report

Chika Thompson Ugwuanyi 1, Uwaezuoke Boniface Odugu 1, 2, *, Ifeanyi Johnson Onyekpa 1, 2, Sunday Gabriel Mba 1, 2, Calistus Obiora Nevo 1, 2, Sylvester Onuegbunam Nweze 1, 2, Emeka Kelvin Ortuanya 1, 2, Fredrick Ikenna Awkadigwe 1, Obiechina Chijioke Eze 1, Innocent Onyemechi Obeta 1, 2, Chike Joachim Maduka 1, 2, Pauline Odinachi Osuagwu 1, Nnanyelugo Chima Ezeora 1, Chukwuka Chude Eze 1, Godwin Ugochukwu Emmanuel 1, Chibunze Chukwunonso Udegbunam 1, Darlington Sunday Sochima Okoh 1, Matthew Okoh 1, Bournaventure Chijioke Nwachukwu 1, Thaddeus Ogbonna Offor 1, Enoch Ejiofor Ogbonna 1, Chukwunonso Nnabuike Ofonere 1, Ernest Ijeoma Uzoho 1, Chioma Nneka Iloabachie 1, Andre Ukamaka Ezike 1, Onyebuchi Osmond Onah 1, Oluchi Ihuoma Opurum 1, Nnamdi Vitalis Udeozor 1, Anthony Okoafor Okpunwa 1, Ndubuisi Joshua Nwankwo 1, Jason Osondu Okonkwo 3 and Chigekwu Nwanne Mekowulu 1

1 Department of Obstetrics and Gynaecology, Enugu State University Teaching Hospital, Parklane, Enugu, Nigeria.
2 College of Medicine, Enugu State University of Science and Technology Enugu, Nigeria.
3 Department of Anaesthesia, Enugu State University Teaching Hospital, Parklane, Enugu, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 33(02), 288–296.
Article DOI: 10.30574/gscbps.2025.33.2.0458
DOI url: https://doi.org/10.30574/gscbps.2025.33.2.0458
Received on 06 October 2025; revised on 13 November 2025; accepted on 15 November 2025
Tranexamic acid (TXA), an antifibrinolytic agent has found favour in the field of obstetrics and gynaecology due to its role in prevention and control of primary postpartum haemorrhage and cases of abnormal uterine bleeding. Tonic clonic seizures have been reported as a rare side effect of intravenous tranexamic acid experienced by patients receiving the drug. We describe a case of a nulliparous woman with abnormal uterine bleeding who developed generalized tonic clonic seizures following intravenous administration of 1g of TXA. She had no other neurological deficits and her electroencephalogram study showed no abnormal wave pattern.
Abnormal Uterine Bleeding; Fibroids; Intravenous; Tranexamic Acid; Seizure
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2025-…

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Chika Thompson Ugwuanyi, Uwaezuoke Boniface Odugu, Ifeanyi Johnson Onyekpa, Sunday Gabriel Mba, Calistus Obiora Nevo, Sylvester Onuegbunam Nweze, Emeka Kelvin Ortuanya, Fredrick Ikenna Awkadigwe, Obiechina Chijioke Eze, Pauline Odinachi Osuagwu, Nnanyelugo Chima Ezeora, Chukwuka Chude Eze, Godwin Ugochukwu Emmanuel, Chibunze Chukwunonso Udegbunam, Darlington Sunday Sochima Okoh, Matthew Okoh, Bournaventure Chijioke Nwachukwu, Thaddeus Ogbonna Offor, Enoch Ejiofor Ogbonna, Chukwunonso Nnabuike Ofonere, Ernest Ijeoma Uzoho, Chioma Nneka Iloabachie, Andre Ukamaka Ezike, Onyebuchi Osmond Onah, Oluchi Ihuoma Opurum, Nnamdi Vitalis Udeozor, Anthony Okoafor Okpunwa, Ndubuisi Joshua Nwankwo, Jason Osondu Okonkwo and Chigekwu Nwanne Mekowulu. Tranexamic Acid Induced Seizure in a Nullipara with Abnormal Uterine Bleeding due to Symptomatic Uterine Fibroids. A Case Report. GSC Biological and Pharmaceutical Sciences, 2025, 33(2), 288-296. Article DOI: https://doi.org/10.30574/gscbps.2025.33.2.0458


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