1 Department of Pharmacy, Faculty of Medicine and Health Science, University of Almahweet, Almahweet, Yemen.
2 Department of Pharmacy, Faculty of Medicine and Health Science, University of Al Hekma Sana'a city, Yemen.
3 Department of Pharmacology, Faculty of pharmacy, University of Science and Technology, Sana'a, Yemen.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 33(01), 230-238.
Article DOI: 10.30574/gscbps.2025.33.1.0408
Received on 14 September 2025; revised on 20 October 2025; accepted on 23 October 2025
Curcuma longa (turmeric) and Trigonella foenum-graecum (fenugreek) are herbs known for anti-inflammatory and wound-healing effects. To formulate and evaluate a topical polyherbal cream from turmeric and fenugreek extracts and test its anti-inflammatory activity. Hydroalcoholic extracts of both plants were prepared and added to different cream bases. The best formulation (F3) was selected after stability testing. Anti-inflammatory activity was studied in 20 rats using the formalin-induced paw edema model for six days. Betamethasone cream was used as the standard. The optimized cream was stable and non-greasy. It showed strong anti-inflammatory effects, similar to betamethasone. A polyherbal cream with turmeric and fenugreek is safe, stable, and effective for dermal inflammation.
Curcuma longa; Trigonella foenum-graecum; Topical formulations; Cream evaluation; Anti-inflammatory activity
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Safia A. Alrezami, Abdulatef M. M. Abbas, Tunis M. Thabet and Mohammad M. alabbasi. Formulation and Evaluation of a Novel Herbal Cream Containing Fenugreek and Turmeric Extracts. GSC Biological and Pharmaceutical Sciences, 2025, 33(1), 230-238. Article DOI: https://doi.org/10.30574/gscbps.2025.33.1.0408