1 Department of tropical medicine and infectious disease, Military Medical Academy, Cairo, Egypt.
2 Department of preventive, social and occupational medicine, Military Medical Academy, Cairo, Egypt.
3 Department of public health, community medicine, environmental and occupational Medicine, Faculty of medicine, Ain Shams University, Cairo, Egypt.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 33(01), 098-115.
Article DOI: 10.30574/gscbps.2025.33.1.0385
Received on 31 August 2025; revised on 07 October 2025; accepted on 10 October 2025
Objective: This study aimed to describe the epidemiology, clinical characteristics, management, and treatment outcomes of patients diagnosed with central nervous system (CNS) infections at a tertiary care hospital in Egypt.
Methods: A retrospective analysis was conducted on 104 patients admitted with suspected CNS infections between July 2021 and October 2023. Data extracted from hospital records included patient demographics, clinical features, laboratory and neuroimaging results, treatment regimens, and final outcomes.
Results: The median patient age was 50 years, with a male predominance (71.2%). The most common diagnoses were encephalitis (45.2%) and meningitis (41.3%). A causative pathogen was identified in only 42.3% of cases, with Streptococcus pneumoniae being the most frequent (13.5%). No etiology was found in 57.7% of cases. Diabetes was the most frequent comorbidity (27.9%). The universal clinical feature was disturbed consciousness, followed by fever and headache. The most used empirical treatment was a combination of ceftriaxone, vancomycin, and acyclovir (57.6%). The overall cure rate was 80.7%, and the mortality rate was 5.7%. All cases of cryptococcal meningitis and 10% of cerebral malaria cases were fatal.
Conclusion: In this cohort, CNS infections primarily affected older adults, with a high rate of unknown etiology. The use of empirical broad-spectrum therapy was associated with a favorable overall outcome. However, the findings highlight an urgent need for enhanced diagnostic methods to identify pathogens, especially in fatal fungal and parasitic infections, to guide targeted treatment and potentially improve survival.
Central nervous system infections; Meningitis; Encephalitis; Epidemiology; Treatment outcomes; Egypt
Preview Article PDF
Mohammad Emam Mohammad, Abou Bakr Farrag, Aisha Abo EL Fotoh and Mohamed Abdel Salam Elgohary. Epidemiology, clinical characteristics, and outcomes of patients having central nervous system infections in Almaza fever military hospital: A retrospective study. GSC Biological and Pharmaceutical Sciences, 2025, 33(1), 098-115. Article DOI: https://doi.org/10.30574/gscbps.2025.33.1.0385