School of Pharmacy, Faculty of Health Sciences, University of Botswana, Plot 4775 Notwane Rd, Gaborone, Botswana.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 32(02), 114-125.
Article DOI: 10.30574/gscbps.2025.32.2.0254
Received on 22 June 2025; revised on 30 July 2025; accepted on 02 August 2025
and anti-inflammatory properties and is commonly used in Botswana's healthcare system both as over the counter and prescription medication.
Aim: This study aimed to evaluate the physicochemical properties, pharmaceutical equivalence, and compliance of three DCF 50 mg tablet brands (S1, S2, S3) with pharmacopeial standards to ensure quality, safety, and efficacy.
Methodology: Eighty coated tablets per brand were assessed for weight variation, hardness, friability, disintegration time, and active ingredient content as stipulated by compendial standards.
Results: All brands complied with USP weight uniformity standards, with significant variations among brands (P<0.05). Friability was within acceptable limits (<1%) for all brands. Active ingredient content ranged from 99.6% (S1) to 104.7% (S3), with no significant purity differences among brands (P>0.05). Disintegration times were 11.42 min (S1), 22.12 min (S2), and 6.44 min (S3), meeting USP limits. Overall, all tested brands complied with USP quality standards, with S1 demonstrating superior physicochemical properties compared to S2.
Conclusion: These findings affirm the quality of diclofenac sodium tablets available in Botswana, supporting their safe and effective use in public health.
NSAIDs; Quality control; Potentiometric titration; United States Pharmacopoeia; Diclofenac sodium
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S. A. Kosoko, B. A. Mopipi and M. O. Tebogo. A physico-chemical analysis of different brands of diclofenac-sodium tablets found in the Gaborone market. GSC Biological and Pharmaceutical Sciences, 2025, 32(2), 114-125. Article DOI: https://doi.org/10.30574/gscbps.2025.32.2.0254