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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

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Allium cameleon extract protects against Aluminum chloride‐induced reproductive toxicity in male rat (Rattus norvegicus) probably by attenuating oxidative damages, inflammatory effect and increasing sexual hormone

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  • Allium Cameleon Extract Protects Against Aluminum Chloride‐induced Reproductive Toxicity In Male Rat (Rattus Norvegicus) Probably By Attenuating Oxidative Damages, Inflammatory Effect and Increasing Sexual Hormone
  • Allium cameleon extract protects against Aluminum chloride‐induced reproductive toxicity in male rat (Rattus norvegicus) probably by attenuating oxidative damages, inflammatory effect and increasing sexual hormone

GRING ZIGLA 1, SIDIKI Neteydji 2, * and ABDOU BOUBA Armand 3

1 Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical sciences, University of Garoua, P.O. Box: 346 Garoua Cameroon.
2 Higher Institute of Sciences, Health Technician and Management of Garoua, Faculty of Medicine and Biomedical sciences, University of Garoua, P.O. Box: 346 Garoua Cameroon.
3 Department of Agriculture, livestock and By Products, National Advanced School of Engineering, University of Maroua, P.O. Box.  46, Maroua Cameroon.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 31(03), 011–026.
Article DOI: 10.30574/gscbps.2025.31.3.0196
DOI url: https://doi.org/10.30574/gscbps.2025.31.3.0196
Received on 12 April 2025; revised on 29 May 2025; accepted on 01 June 2025
 
Objective: The aim of this study is to investigate effects of Allium cameleon Cronquist (1981) (Liliaceae) a bulb belonging to the garlic family, on reproductive toxicity induced by aluminum chloride, known as a medicinal plant used for its aphrodisiac activities in Cameroonian folk medicine. The current investigation was carried out to evaluate the protective potentials of Allium cameleon extracts and study its possible mechanisms by which this could be accomplished
Methods: The behavioral and biochemical tests were used to detect the protective properties. The conceivable mechanisms of action of the extracts were investigated through determination of sexual hormones, nitric oxide, cGMP, anti-inflammatory and antioxidant activities in male rats treated with aluminum chloride and plant extract.
Results: Aluminum chloride caused reproductive toxicity by decreasing sexual excitement, semen quality, and the concentrations of testosterone, FSH and LH. Levels of endogenous antioxidant enzymes (CAT, SOD, and GSH) were worsened. Inflammatory parameters were improved.  Allium cameleon thwarted all these parameters. Penile nitric oxide and cGMP levels were boosted. Significant stimulation in sexual behavior, elevated spermatic production, raised of viability, morphology, count and sperm mobility were also observed. Treated animals exhibited elevated levels of endogenous antioxidant enzymes and inflammatory cytokines were decreased.
Conclusion: These discoveries suggest that Allium cameleon protects animals against reproductive toxicity that might be involve in the attenuation of oxidative and inflammatory damage, but also in the increase of sexual hormones production and NO/cGMP cascade.
Allium Cameleon; Reproductive Toxicity; Aluminum Chloride; Sexual Hormones; Folk Medicine.
 
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2025-…

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GRING ZIGLA, SIDIKI Neteydji and ABDOU BOUBA Armand. Allium cameleon extract protects against Aluminum chloride‐induced reproductive toxicity in male rat (Rattus norvegicus) probably by attenuating oxidative damages, inflammatory effect and increasing sexual hormone. GSC Biological and Pharmaceutical Sciences, 2025, 31(3), 011-026. Article DOI: https://doi.org/10.30574/gscbps.2025.31.3.0196


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