Formulation and evaluation of herbal gel (Clerodendrum Serratum Linn) blue glory

Clerodendrum serratum Linn. (Family: Verbenaceae) is very widely distributed in tropical and subtropical regions of the world. Ethno-medicinal importance of the plant has been reported in various indigenous systems of medicines like Ayurveda, Siddha and Unani for the treatment of various life-threatening diseases. The roots of C. serratum are also used as anti-oxidant, anti-bacterial, and anti-fungal. Besides these the antimicrobial value of this herbal plant have also been reported in its stems and leaves. These reports are very encouraging and indicate that herb should be studied more expensively for its therapeutic benefits. Various minerals like Na, Mg, Al, Ca etc. saponins, terpenoids, D-mannitol are the phytoconstituents present in the plant.

The present research reflected towards exploring the plausible role(s) of the active extracts of Clerodendrum Serratum (leaves), Aloe vera gel , Honey formulated as Herbal Gel product. The formulation were characterized by determining the pharmaceutical characteristics like skin irritancy test, pH, appearance, viscosity, spreadability, extrudability, swelling index, and washability. Further, wound healing activity was studied . The phytochemical constituents such as alkaloids, flavonoids, glycosides, tannins, carbohydrates, sterols, saponins, proteins, and other miscellaneous phenolic components are believed to play a pivotal role in the healing of the wound by significantly increasing the rate of wound closure and rate of epithelization. This finding provided an insight into the applications of the herbal formulations in the traditional treatment of serious wound conditions and also rejuvenating the ethnopharmacological principles in context to modern medicine.

Thus, this paper highlights the various pharmacological activities of Clerodendrum serratum and formulation of herbal gel and its further scope for clinical utility.