Effects of flavonoid extract from wonderful Kola (Buchholzia Coriacea) seed on antioxidant and liver function biomarkers of fructose fed streptozotocin induced type 2 diabetic albino rats

Wonderful kola is a wonderful herb with excellent healing powers, the seeds is fast gaining reputation because it appears to be a treatment to nearly all ailments. This study evaluates the potential hepatoprotective and antioxidant effects of oral administration of flavonoid-rich seed extract of Buchholzia coriacea seeds in fructose fed Streptozotocin (STZ)-induced diabetic rats. Twenty-five (25) rats were used for this study. They were divided into five (5) groups of five rats each; normal control, negative control (Streptozotocin (STZ)-induced diabetic), positive control (Glibenclamide), 100mg/kg of body weight seed extract and 500mg/kg of body weight seed extract. The flavonoid seed extract of the plant significantly (P<0.05) reduced liver damage caused by STZ, as evidenced by the decreased serum alanine amino transferase and aspartate amino transferase activity, compared to in the group treated with STZ alone. The result of the Superoxide dismutase activity (SOS) shows more antioxidant activity than other antioxidant parameters. However, that of catalase enzyme has the lowest activity as compared to Thiobarbituric acid reactive species (TBARS) and Reduced Glutathione (GSH) activities. All were significantly (P<0.05) improved following the treatments of flavonoid extract. In conclusion, the results show that seeds of Buchholzia coriacea contain a potent antioxidant and hepatoprotective effects, which can give scientific merit to the traditional use of the extract in the management of diabetes and the improvement of its complications.