Design and development of minoxidil-loaded nano carrier-based transdermal gel of trans-ethosomes for transdermal delivery system: Invitro evaluation studies

The present aim of the study was to develop a transdermal drug delivery system of the Nano-carrier-based Minoxidil-loaded transethosomal gel. In this study, we used Soyaphopshotidylcholine as a vesicle-forming agent and Sodium deoxycholate as a surfactant, and vesicle stabilizer as excipients. The Minoxidil transethosomes were prepared by thin film hydration technique. The prepared Minoxidil-loaded transethosomes (MTE) were evaluated and the particle size (189.83nm and 206.18nm), PDI(0.292 and 0.263), Zeta potential(-29.1mv and-28.2mv) and the entrapment efficiency (89.16±3.16 and 81.65±2.74) of MTE5 and MTE6. The MTE dispersion was further used to prepare gel, the gel base was prepared by using Carbopol, Xanthan gum, and HPMC K15. The optimized MTE-gel formulation was further evaluated, and the cumulative percentage of drug release was 98%, the 3 months stability studies show satisfactory results indicating good gel stability.