Antioxidant and antiamylase activities of leaf and root extracts of Ziziphus mauritiana Lam

Ziziphus mauritiana Lam is a plant species widely used in Mali for its medical virtues to treat various diseases including Diabetes. The present study aims to examine the antioxidant and antidiabetic activities of leaf and root extracts of Z. mauritiana Lam collected in Bamako. Phytochemical screening and assay were carried out using conventional methods. The DPPH test was used to evaluate the anti-radical activity, and the antidiabetic potential of the extracts was estimated via the α-amylase inhibition test. Characterization tests revealed the presence of free tannins, flavonoids, coumarins, terpenoids, triterpenes, alkaloids, saponins and anthraquinones in all our extracts. The root extracts revealed higher contents of polyphenols (561.40±22.4 to 218.00±30.2 mg EAG/g) and flavonoids (54.26±4.9 to 132.56±6, 82 mg EQ/g) whatever the solvent, with the exception of Ethyl Acetate. Ethanol extracts showed the best anti-radical potentiel. The IC₅₀ was 58.13±1.85 µg/mL for roots and 85.19±0.415 µg/mL for leaves. The results provide a better understanding of the medicinal properties of Z. mauritiana Lam and pave the way for management strategies for diabetes and diseases associated with oxidative stress.