Synthesis of 3-(substitutedthiocarbamide)-aniline derivatives from di-tert-butyl dicarbonate (BoC) protected 3-chloroaniline

Synthesis of substituted thiocarbamide derivatives is important in the fields of medicinal, agricultural, chemical, and pharmaceutical. Thiocarbamides are commonly utilized as starting materials for several organic synthetic processes and have been studied in search for easy and effective methods of chemical synthesis. In the existing research work, 3-chloroaniline was protected by a di-tert-butyl dicarbonate (BoC) protecting agent. Substituted thiocarbamide derivatives were synthesized using condensation of various substituted thioureas with amino group-protected 3-chloroaniline. The structures of all compounds of 3(substitutedthiocarbamido)-aniline were characterized by ¹H-NMR, ¹³C-NMR, FT-IR, LCMS and CHNS elemental analysis.