Home
GSC Biological and Pharmaceutical Sciences
Peer-reviewed Journal | Impact factor 8.1 | ISSN: 2581-3250 | CAS Source Indexed | Crossref DOI

Main navigation

  • Home
    • Journal Information
    • Editorial Board Members
    • Reviewer Panel
    • Abstracting and Indexing
    • Journal Policies
    • Our CrossMark Policy
    • Publication Ethics
    • Issue in Progress
    • Current Issue
    • Past Issues
    • Instructions for Authors
    • Article processing fee
    • Track Manuscript Status
    • Get Publication Certificate
    • Join Editorial Board
    • Join Reviewer Panel
  • Contact us
  • Downloads

Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

🌟 GSC Biological and Pharmaceutical Sciences (GSCBPS) 🌟

Low Publication Charges | Fast Editorial Processing | Crossref DOI Linking | Transparent Peer-Review Process

Publishing quality research in Biological Sciences, Pharmaceutical Sciences, Medicine, Healthcare and Allied Life Sciences.

e-ISSN: 2581-3250 | Impact Factor: 8.1 | Established: 2017 | Charges: USD 35 / INR 2100

📄 Submit Manuscript 👉 Author Guidelines 📚 Published Articles 

The role of CYP2D6 in the metabolism of antidepressants

Breadcrumb

  • Home
  • The Role of CYP2D6 In The Metabolism of Antidepressants
  • The role of CYP2D6 in the metabolism of antidepressants

Ximena-Chávez 1, Adrian-Corral 1, Denisse-Hernández 1, *, Hugo-Alberto-Ortiz 1 and Brissia-Lazalde 2

1 Medicine and Nutrition Faculty Juarez University of Durango State. Durango, Dgo., México, downton area.
2 Genetic Department, Medicine and Nutrition Faculty, Juarez University of Durango State, Durango, Dgo., México.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 27(03), 154–160.
Article DOI: 10.30574/gscbps.2024.27.3.0232
DOI url: https://doi.org/10.30574/gscbps.2024.27.3.0232
Received on 04 May 2024; revised on 15 June 2024; accepted on 18 June 2024
The cytochrome P450 2D6 plays an important role in the metabolism of several drugs, including antidepressants, and it also influences their efficacy and adverse effects. Some of the CYP2D6 genetic variants are closely related with a different metabolism way, depending on its type (PM, MI, normal, UM); that impacts mostly reducing the pharmacologic effects of drugs like haloperidol, duloxetine, venlafaxine, nortriptyline, paroxetine and others because their metabolism depends mainly from CYP2D6.
All of these reduced effects can impact negatively in the treatment of depression because they reduce its half-life elimination, and therefore also leads to reduce the acting time and maxim effect, which results in decreased therapeutic effect. Therefore, an alternative to improve the effectiveness of the treatment is to change it for an antidepressant which is not metabolized by CYP2D6.
CYP2D6; Genetic variant; Antidepressants; Depression; Metabolism; Ultra-rapid
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2024-…

Preview Article PDF

Ximena-Chávez, Adrian-Corral, Denisse-Hernández, Hugo-Alberto-Ortiz and Brissia-Lazalde. The role of CYP2D6 in the metabolism of antidepressants. GSC Biological and Pharmaceutical Sciences, 2024, 27(3), 154-160. Article DOI: https://doi.org/10.30574/gscbps.2024.27.3.0232


📝 Copyright, Licensing and Permissions: © Copyright Author(s). This article is published under the 🌐 Creative Commons Attribution 4.0 International License (CC BY 4.0) , which permits unrestricted use, distribution, adaptation, and reproduction in any medium, provided the original author(s) and source are properly credited, a link to the license is provided, and any changes made are indicated.


⚠️ Disclaimer: The statements, opinions, interpretations, and data presented in this publication are solely those of the individual author(s). GSC Biological and Pharmaceutical Sciences (GSCBPS), the editors, reviewers, editorial board, and publisher disclaim responsibility for any errors, omissions, or consequences arising from the use of the information contained in this article.


🏆 Get Publication Certificate 📄 Download Letter of Acceptance 🔗 Verify Crossref DOI 📘 View Issue Cover Page 👨‍🔬 Editorial Board 📑 Table of Contents 

🚀 Publish Your Research in International Peer Reviewed Open Access Journal - GSC Biological and Pharmaceutical Sciences (GSCBPS)

Submit your manuscripts from Biological Sciences, Pharmaceutical Sciences, Medicine, Healthcare, Biotechnology and Allied Life Sciences etc.

🌍 International Journal   |   👨‍🔬 Transparent Peer Review Process   |   🌐 Open Access Publishing   |   🔗 Crossref DOI 
⚡ Fast Editorial Processing   |   💰 Low Publication Charges

📝 Submit Your Manuscript 📘 Author Guidelines 💰 Publication Charges 

✅ No Submission Fee •  📜 Free Publication Certificate • 🌍 Global Visibility

⭐ Popular Pages


  • 🌍 International Journal
  • 🌐 Open Access Journal
  • 👨‍⚖️ Peer-Reviewed Journal
  • 💰 Low APC Journal
  • 🚀 Fast Publication Journal
  • ⚡ Fast-Track Peer-Review
  • 🔗 Crossref DOI Journal
  • 📖 Refereed Journal
  • 📈 High Impact Journal
  • 🧬 International Biology Journal
  • 💊 International Pharmacy Journal
  • 📝 Publish Research Paper

✍️ Author Resources


  • 📝 Publish Research Paper
  • 📖 Author Guidelines
  • 🎯 Aims and Scope
  • 💳 Article Processing Charges
  • 📤 Submit Manuscript
  • 📄 Cover Letter
  • ✍️ Author Declaration Form
  • 📄Track Manuscript Status
  • 📜 Get Publication Certificate
  • 📚 Journal Past Issue Archive
  • 🔎 Journal Indexing

⚖️ Journal Policies


  • ⚖️ Publication Ethics
  • 🛡️ Plagiarism Policy
  • 👨‍🔬 Peer Review Policy
  • 👨‍⚖️ Peer Review Process
  • 📖 Open Access Publishing
  • 📜 Copyright & Licensing
  • 🔗Author Self-Archiving Policy
  • 👥 Authorship Policy
  • 📊 Data Sharing Policy
  • 🤖 AI Usage Policy

Copyright © 2026 GSC Biological and Pharmaceutical Sciences - All rights reserved

Developed & Designed by VS Infosolution