Home
GSC Biological and Pharmaceutical Sciences
Peer-reviewed Journal | Impact factor 8.1 | ISSN: 2581-3250 | CAS Source Indexed | Crossref DOI

Main navigation

  • Home
    • Journal Information
    • Editorial Board Members
    • Reviewer Panel
    • Abstracting and Indexing
    • Journal Policies
    • Our CrossMark Policy
    • Publication Ethics
    • Issue in Progress
    • Current Issue
    • Past Issues
    • Instructions for Authors
    • Article processing fee
    • Track Manuscript Status
    • Get Publication Certificate
    • Join Editorial Board
    • Join Reviewer Panel
  • Contact us
  • Downloads

Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

🌟 GSC Biological and Pharmaceutical Sciences (GSCBPS) 🌟

Low Publication Charges | Fast Editorial Processing | Crossref DOI Linking | Transparent Peer-Review Process

Publishing quality research in Biological Sciences, Pharmaceutical Sciences, Medicine, Healthcare and Allied Life Sciences.

e-ISSN: 2581-3250 | Impact Factor: 8.1 | Established: 2017 | Charges: USD 35 / INR 2100

📄 Submit Manuscript 👉 Author Guidelines 📚 Published Articles 

The capability of Piper betle leaves ethanolic extract to inhibit neutrophil infiltration in sepsis-induced BALB/c Mice

Breadcrumb

  • Home
  • The Capability of Piper Betle Leaves Ethanolic Extract To Inhibit Neutrophil Infiltration In Sepsis-induced BALB/c Mice
  • The capability of Piper betle leaves ethanolic extract to inhibit neutrophil infiltration in sepsis-induced BALB/c Mice

Shod Abdurrachman Dzulkarnain 1, *, Irene Ratridewi 2, Yessy Chairani Puspita Sari 3, Vanianisa Hanareta Hantoko 3 and Dewi Santosaningsih 4

1 Department of Medical Science, Faculty of Medicine, Universitas Negeri Surabaya, Surabaya, East Java, 60213, Indonesia.
2 Department of Pediatrics of dr. Saiful Anwar General Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
3 Medical Degree, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
4 Department of Clinical Microbiology of dr. Saiful Anwar General Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 26(03), 212–216.
Article DOI: 10.30574/gscbps.2024.26.3.0103
DOI url: https://doi.org/10.30574/gscbps.2024.26.3.0103
Received on 13 February 2024; revised on 25 March 2024; accepted on 28 March 2024
Background: Sepsis due to ESBL-producing Escherichia coli infection requires innovative management to prevent a higher prevalence of meropenem overuse. The antimicrobial effect of Piper betle leaves ethanolic extract has been previously proven and should be tested on sepsis-induced animal models.
Objectives: This study assesses the antimicrobial effect of Piper betle leaves ethanolic extract towards the bacterial loads and its anti-inflammatory effect on neutrophil infiltration in the lung, kidney, and liver of sepsis-induced mice.
Methods: After sepsis inducement, 3 mg/mL of Piper betle leaves ethanolic extract was administered orally. After the mice died, the bacterial load of the lung, kidney, and liver was measured, while neutrophil infiltration was observed using hematoxylin-eosin staining.
Results: There is no significant decreasing the number of bacterial loads in the treatment group but there is a significant decrease in the number of neutrophils infiltration in the treatment group.
Conclusion: Single dose administration of Piper betle leaves ethanolic extract is sufficient to inhibit neutrophil infiltration significantly.
Piper betle ethanolic extract; ESBL-producing Escherichia coli; sepsis-induced mice; Bacterial load; Neutrophil infiltration
 
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2024-…

Preview Article PDF

Shod Abdurrachman Dzulkarnain, Irene Ratridewi, Yessy Chairani Puspita Sari, Vanianisa Hanareta Hantoko and Dewi Santosaningsih. The capability of Piper betle leaves ethanolic extract to inhibit neutrophil infiltration in sepsis-induced BALB/c Mice. GSC Biological and Pharmaceutical Sciences, 2024, 26(3), 212-216. Article DOI: https://doi.org/10.30574/gscbps.2024.26.3.0103


📝 Copyright, Licensing and Permissions: © Copyright Author(s). This article is published under the 🌐 Creative Commons Attribution 4.0 International License (CC BY 4.0) , which permits unrestricted use, distribution, adaptation, and reproduction in any medium, provided the original author(s) and source are properly credited, a link to the license is provided, and any changes made are indicated.


⚠️ Disclaimer: The statements, opinions, interpretations, and data presented in this publication are solely those of the individual author(s). GSC Biological and Pharmaceutical Sciences (GSCBPS), the editors, reviewers, editorial board, and publisher disclaim responsibility for any errors, omissions, or consequences arising from the use of the information contained in this article.


🏆 Get Publication Certificate 📄 Download Letter of Acceptance 🔗 Verify Crossref DOI 📘 View Issue Cover Page 👨‍🔬 Editorial Board 📑 Table of Contents 

🚀 Publish Your Research in International Peer Reviewed Open Access Journal - GSC Biological and Pharmaceutical Sciences (GSCBPS)

Submit your manuscripts from Biological Sciences, Pharmaceutical Sciences, Medicine, Healthcare, Biotechnology and Allied Life Sciences etc.

🌍 International Journal   |   👨‍🔬 Transparent Peer Review Process   |   🌐 Open Access Publishing   |   🔗 Crossref DOI 
⚡ Fast Editorial Processing   |   💰 Low Publication Charges

📝 Submit Your Manuscript 📘 Author Guidelines 💰 Publication Charges 

✅ No Submission Fee •  📜 Free Publication Certificate • 🌍 Global Visibility

⭐ Popular Pages


  • 🌍 International Journal
  • 🌐 Open Access Journal
  • 👨‍⚖️ Peer-Reviewed Journal
  • 💰 Low APC Journal
  • 🚀 Fast Publication Journal
  • ⚡ Fast-Track Peer-Review
  • 🔗 Crossref DOI Journal
  • 📖 Refereed Journal
  • 📈 High Impact Journal
  • 🧬 International Biology Journal
  • 💊 International Pharmacy Journal
  • 📝 Publish Research Paper

✍️ Author Resources


  • 📝 Publish Research Paper
  • 📖 Author Guidelines
  • 🎯 Aims and Scope
  • 💳 Article Processing Charges
  • 📤 Submit Manuscript
  • 📄 Cover Letter
  • ✍️ Author Declaration Form
  • 📄Track Manuscript Status
  • 📜 Get Publication Certificate
  • 📚 Journal Past Issue Archive
  • 🔎 Journal Indexing

⚖️ Journal Policies


  • ⚖️ Publication Ethics
  • 🛡️ Plagiarism Policy
  • 👨‍🔬 Peer Review Policy
  • 👨‍⚖️ Peer Review Process
  • 📖 Open Access Publishing
  • 📜 Copyright & Licensing
  • 🔗Author Self-Archiving Policy
  • 👥 Authorship Policy
  • 📊 Data Sharing Policy
  • 🤖 AI Usage Policy

Copyright © 2026 GSC Biological and Pharmaceutical Sciences - All rights reserved

Developed & Designed by VS Infosolution