Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®

Zaïnab Kajeiou; Issam Mokhtari; Loubna Yacoubi; Amina Himri; Dounia El Moujtahide; El Houcine Sebbar; Mohammed Choukri

doi:10.30574/gscbps.2024.26.2.0068

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Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®

Zaïnab Kajeiou ^{1, 2, *}, Issam Mokhtari ^{1, 2}, Loubna Yacoubi ^{1, 2}, Amina Himri ^{1, 2}, Dounia El Moujtahide ^{1, 2}, El Houcine Sebbar ^{1, 2} and Mohammed Choukri ^{1, 2}

1 Mohammed First University, Faculty of Medicine and Pharmacy of Oujda, Morocco.

2 Central Laboratory, Mohammed VI University Hospital, Oujda, Morocco.

Research Article

GSC Biological and Pharmaceutical Sciences, 2024, 26(02), 199–205.

Article DOI: 10.30574/gscbps.2024.26.2.0068

DOI url: https://doi.org/10.30574/gscbps.2024.26.2.0068

Publication history

Received on 09 January 2024; revised on 17 February 2024; accepted on 20 February 2024

Abstract

In the evolving landscape of clinical diagnostics, the significance of folate takes center stage as precision and innovation shape advancements in analytical methodologies. Folate, a pivotal element in cellular metabolism, governs physiological processes and serves as an indicator for various medical conditions. This study employs the Chemiluminescent Microparticle Immunoassay (CMIA), known for its accuracy, to assess the reproducibility and repeatability of serum folate levels.

Folate's role in cellular metabolism influences diverse physiological functions, making its precise quantification crucial for identifying and monitoring conditions such as folate deficiency. The CMIA method emerges as a robust approach, leveraging immunological specificity for high precision and reliability.

Utilizing the Abbott Alinity ci ^®Analyzer, a technologically advanced clinical chemistry instrument, this study incorporates a systematic analytical method verification procedure. This involves quantification through a standardized protocol and a comparative analysis against criteria set by esteemed societies (RICOS and FSCB), ensuring comprehensive insights into analysis techniques.

The reproducibility test, evaluating the impact of various factors on assay results, reveals low Coefficient of Variation (CV) values (CV1: 10.25%, CV2: 8.58%, CV3: 9.13%) across different levels. The results align with quality control limits, emphasizing the method's reliability. Repeatability assessment demonstrates exceptionally low CV values (CV1: 4.84%, CV2: 3.41%, CV3: 1.89%), highlighting the method's stability and precision under controlled conditions.

Keywords

Serum Folate assay; Abbott Alinity ci analyzer; precision; Reliability; Biochemistry laboratory; Mohammed VI University Hospital; Reproducibility assessment; Repeatability testing; Chemiluminescent microparticle immunoassay method; CMIA

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Zaïnab Kajeiou, Issam Mokhtari, Loubna Yacoubi, Amina Himri, Dounia El Moujtahide, El Houcine Sebbar and Mohammed Choukri. Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®. GSC Biological and Pharmaceutical Sciences, 2024, 26(2), 199-205. Article DOI: https://doi.org/10.30574/gscbps.2024.26.2.0068

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Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®

Zaïnab Kajeiou ^{1, 2, *}, Issam Mokhtari ^{1, 2}, Loubna Yacoubi ^{1, 2}, Amina Himri ^{1, 2}, Dounia El Moujtahide ^{1, 2}, El Houcine Sebbar ^{1, 2} and Mohammed Choukri ^{1, 2}

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Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®

Zaïnab Kajeiou 1, 2, *, Issam Mokhtari 1, 2, Loubna Yacoubi 1, 2, Amina Himri 1, 2, Dounia El Moujtahide 1, 2, El Houcine Sebbar 1, 2 and Mohammed Choukri 1, 2

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Zaïnab Kajeiou ^{1, 2, *}, Issam Mokhtari ^{1, 2}, Loubna Yacoubi ^{1, 2}, Amina Himri ^{1, 2}, Dounia El Moujtahide ^{1, 2}, El Houcine Sebbar ^{1, 2} and Mohammed Choukri ^{1, 2}