Formulation and evaluation of bilastine loaded solid Self-Nano Emulsifying Drug Delivery System (s-SNEDDS) for oral administration: In-vitro characterization

The aim of this study was to prepare an oral administrable SNEDDS for poorly water soluble drugs Bilastine. To choose the SNEDDS excipients, a ternary phase diagram and solubility assessment were conducted. A components of oil (capmul PG-NF) surfactant (Tween 40) and co-surfactant (Capryol 90) were used as the excipients. The optimized formulation was characterized for In-vitro analysis. The prepared S-SNEDDs exhibited good flow characteristics and Particle size (148.5dnm), zeta potential (−28.6), PDI (0.242), drug loading efficiency, % CDR of the optimized S-SNEDDs [TP3PG1 (2:8)] was found to be 103.61 ±0.678, 98.65% respectively. The formulation was stable over a 3-month storage period at 25 ◦C and 4 ◦C in terms of particle size, physical appearance, and drug loading. Overall, a range of lipid based SNEDDS liquid, solid formulations were successfully developed and seem to be a promising alternative to improving the solubility of poorly water-soluble drugs and evaluating In-vitro characterizations.