A PKPD interaction between Momordica charantia and oral hypoglycemic drug –dapagliflozin in STZ induced hyperglycemic rats

Traditional medications obtained from the   medicated   herbal plants are used by about maximum percentage of world population for different chronic disease condition. Diabetes (Hyperglycemia- high blood sugar level) is a very important metabolic disorder in different developed, developing countries including India. It providing to very serious complications on health of human beings, especially in the rural and subruralareas. Hence, the research studies required to be subjected to pharmacodynamic and pharmacokinetic studies in order to determine effect of Momordica charantia  herb on the hyperglycaemic patients who are taking the therapy with synthetic drugs. This study was to discover the influence of Momordica charantia on the pharmacokinetics and pharmacodynamics of Dapagliflozinand in rats. Results have proved the negative (decrease) effect of Momordica charantia on pharmacokinetics but positive (increase) effect on pharmacodynamics of Dapagliflozin.