1 Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Republic of Cameroon.
2 Department of Galenic Pharmacy and Pharmaceutical Legislation, Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Republic of Cameroon.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 23(02), 133–141.
Article DOI: 10.30574/gscbps.2023.23.2.0185
Received on 27 March 2023; revised on 10 May 2023; accepted on 13 May 2023
Following studies made on the standardization of a traditional recipe made of Albizia ferruginea and Newbouldia laevis, we carried out studies on pharmacological effects on microorganisms found on dermatosis: two bacteria Staphylococcus aureus, Pseudomonas aeruginosa and three species of Epidermophyton.
Materials and Methods: Following the harvest of the truck pulps of Albizia ferruginea and Newbouldia laevis at Eloundem, they were dry for a week in an ambient environment, followed by a grinding to a granular powdered form. A powder mass of 250 g was used for the extract, using a Soxhlet from BEHR LABOR-TECHNIK. Therefore, a mixture of ethanol-water in a volume ratio of 70/30 was used as a solvent. The renewal of fungi strain was made by regeneration and viability testing phase. The antifungal antivity was made using Disc diffusion method and the broth dilution method.
Results: MICs were respectively: MIC was 12.5 mg/mL on Staphyloccocus aureus and 6.25 mg/mL on Pseudomonas aeruginosa; Trichophyton rubrum: 250 mg/mL for Albizia ferruginea and 250 mg/mL for Newbouldia laevis; Trichophyton interdigitale: 125 mg/mL for Albizia ferruginea and 125 mg/mL for Newbouldia laevis; Trichophyton violaceum: 125 mg/mL for Albizia ferruginea and 250 mg/mL for Newbouldia laevis.
Conclusions: Our different plant extracts would be a possibility to explore in the study of in vivo antibacterial and anti-dermatophytic activities.
Albizia ferruginea; Newbouldia laevis; Traditional medicine Africa; Dermatosis; Antimicrobial; Plant extracts
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Aude Périne MINYEM NGOMBI-AFUH, NNANGA NGA and Joseph NGOUPAYO. The pharmacological activities of Albizia ferruginea and Newbouldia laevis on Pseudomonas aeruginosa, Staphylococcus aureus and Epidermophyton species. GSC Biological and Pharmaceutical Sciences, 2023, 23(2), 133-141. Article DOI: https://doi.org/10.30574/gscbps.2023.23.2.0185