Toxicity test of cream from an extract mixture of turmeric and tamarind leaves as antiaging

Cream from a mixture of turmeric and tamarind leaves extract needs to be tested for its toxicity to really make sure it doesn't have side effects. The purpose of this study was to test the toxicity of a mixture of turmeric and tamarind leaves extract cream using Wistar rats. This study used rats as experimental animals which were carried out in 2 stages, namely preliminary tests using 5 groups of experimental animals. After adaptation the experimental animals were given cream doses of 50, 200, 1000, 2000 mg/kg bw. The second stage was carried out after the results of the first stage showed symptoms of toxicity and death. The second stage used two groups of rats (3 each), namely the treatment group using the largest dose of cream that did not cause death and the control group which was a placebo. In addition, observations of collagen content were also carried out. The results showed that the turmeric and tamarind extract cream did not have toxic properties. The skin of rats that were given turmeric and tamarind extract cream produced higher collagen content and was different from the other groups.