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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

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Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine

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  • Formulation and Evaluation of Solid Dispersion Method Based Fast Dissolving Tablet of Cilnidipine
  • Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine

Hitesh Jain *, Vimla Chaudhary, Vaishnavi Kamath, Dipal Prajapati and D. B. Meshram

Department of Pharmaceutics, Pioneer Pharmacy Degree College, Vadodara 390019, Gujarat, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 22(01), 345–350.
Article DOI: 10.30574/gscbps.2023.22.1.0039
DOI url: https://doi.org/10.30574/gscbps.2023.22.1.0039
Received on 09 December 2022; revised on 21 January 2023; accepted on 24 January 2023
 
Background: The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine.
Method: To enhance the solubility of cilnidipine solvent evaporation method was used. In solvent evaporation method polymer like HPMC, PVP K30, PEG 4000 and PEG 6000(for binary solid dispersion) and poloxamer 188(for ternary solid dispersion) were used in the different drug polymer ratio.
Conclusion: Among them cilnidipine: HPMC: poloxamer 188 shows better solubility and also different physical characterization test like DSC and XRD. After selection of best ternary solid dispersion fast dissolving tablets of cilnidipine were prepared using direct comp ration method via using different super disintegrant.
 
Cilnidipine; Solid dispersion; Fast dissolving tablet; Poloxamer; Ternary complex
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2023-…

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Hitesh Jain, Vimla Chaudhary, Vaishnavi Kamath, Dipal Prajapati and D. B. Meshram. Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine. GSC Biological and Pharmaceutical Sciences, 2023, 22(1), 345-350. Article DOI: https://doi.org/10.30574/gscbps.2023.22.1.0039


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