Approaches to Improve bioavailability and oral absorption of low water-soluble drug by self- emulsifying drug delivery system

Self-emulsifying drug delivery system (SEDDS), a type of lipid-based technology which are isotropic mixtures of oil, surfactant, solvent, and co-solvents generated by the activity of liquid or solid self-emulsifying ingredients onto powders. It shown interest in the recently for enhancement of solubility and bioavailability of poorly water-soluble drugs (BCS-II). With the novelty of research in this field, novel Excipients have been design with novel properties for enhances solubility, Bioavailabity and oral absorption to achieving target response. Self-emulsifying drug delivery systems (SEDDS) emerged as an insightful approach for delivering highly hydrophobic entities to enhance their bioavailability. SEDDS increase drug bioavailability in addition to improving the solubility of poorly soluble drugs by a number of additional potential pathways, such as avoiding the hepatic first-pass effect, blocking P-gp efflux, and overcoming resistance to metabolism by the cytochrome P450 family of enzymes in the gut and liver. Conventional SEDDS were developed in a liquid form which owned numerous overcome like low stability and drug loading efficiency, fewer choices of dosage forms and irreversible precipitation of drug or excipients. To address these curbs solid-SEDDS (S-SEDDS) was introduced as an efficient strategy that combined advantages of solid dosage forms such as increased stability, portability and patient compliance along with substantial improvement in the bioavailability. This review highlights parts of SEDDS, and their characterization evaluation. Which are completely summarized via different techniques.