Critical appraisal of multiple sclerosis guideline in Indonesia

Multiple sclerosis (MS) is an autoimmune disease and an incurable. The MS guideline is available in Indonesia. The guideline was developed by Indonesian Neurological Association. The appraisal of these guideline is not yet performed. The aim of this study is to assess the quality of multiple sclerosis guidelines in Indonesia using Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument. The search was obtained to identify MS guideline in Indonesia. The guideline assessed using AGREE II instrument. There are 23 key items organized within 6 domains and each key items were rated on a 7-point scale. After calculating each domain, the result interpreted as: (i) a strongly recommended for use in practice, (ii) recommended for use with some modification, or (iii) not recommended for use in practice. There was only one MS guideline in Indonesia, developed by Indonesian Neurological Association called “Perdossi” in 2015. Most of the domain score percentage were more than 50%. Domain 4 got the highest score percentage (94.44%), followed by domain 2 (88.89%), domain 1 (83.33%), and domain 5 (54.17%). The guideline had a spesific recommendations and easily identifiable in an algorithms, tables, or summary boxes. The guideline’s objectives, target populations, target users, and development group were clearly described. The lowest score percentage was domain 6 (33.33%) because lack of related informations. Critical appraisal of the Indonesian MS guideline using AGREE II instrument showed a good result. The Indonesian MS guideline was strongly recommended for use in practice.