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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

🌟 GSC Biological and Pharmaceutical Sciences (GSCBPS) 🌟

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Intrarenal injection of silica mesoporous reduced renal toxicity induced by gentamycin in rats

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  • Intrarenal Injection of Silica Mesoporous Reduced Renal Toxicity Induced By Gentamycin In Rats
  • Intrarenal injection of silica mesoporous reduced renal toxicity induced by gentamycin in rats

Tahani Younis Omar 1, Sara Bayoumi Ali 2, Rokia Gamal Mohamed 2, Ahmed Osama Abdelaty 2, Liali Yousef Talat 2, Ahmed Mostafa Fahmy 2, Ayman Saber Mohamed 2, *, Sohair Ramadan Fahmy 2 and May Mohamed El Batran 3

1 Department of zoology, Faculty of science, Sirte University. Sirte Libya.
2 Department of Zoology. Faculty of Science, Cairo University, Egypt.
3 Faculty of Pharmacy, Cairo University, Egypt.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 19(01), 061–065.
Article DOI: 10.30574/gscbps.2022.19.1.0138
DOI url: https://doi.org/10.30574/gscbps.2022.19.1.0138
Received on 01 March 2022; revised on 04 April 2022; accepted on 06 April 2022
Introduction: Mesoporous silica (MS) has recently used in biomedical applications due to its distinctive physicochemical properties.
Purpose: The study aims to investigate the efficacy of MS to reduce renal toxicity induced by gentamicin in rats.
Methods: The rats were randomly divided into three groups (n=6 per group): Control group (injected with 0.9% saline i.p daily for 8 consecutive), Gentamycin (injected with gentamycin, 100 mg/kg bw i.p. for 8 consecutive days) and MS group (after gentamycin injection, rat injected into left kidney with MS; 70 μg/0.5 ml/ rat).
Results: Ms Treatment caused significant decreases in creatinine, urea, uric acid, and MDA while it increased GSH and catalase levels.
Conclusion: Intrarenal injection of MS improved renal function in rats suffering from acute kidney injury.
Acute Kidney Injury; Mesoporous Silica; Intrarenal Injection; Gentamycin
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2022-…

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Tahani Younis Omar, Sara Bayoumi Ali, Rokia Gamal Mohamed, Ahmed Osama Abdelaty, Liali Yousef Talat, Ahmed Mostafa Fahmy, Ayman Saber Mohamed, Sohair Ramadan Fahmy and May Mohamed El Batran. Intrarenal injection of silica mesoporous reduced renal toxicity induced by gentamycin in rats. GSC Biological and Pharmaceutical Sciences, 2022, 19(1), 061-065. Article DOI: https://doi.org/10.30574/gscbps.2022.19.1.0138


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