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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

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Verification of the analytical performance of the serum CA 125 assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda

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  • Verification of The Analytical Performance of The Serum CA 125 Assay On The Abbott Alinity Ci®: Experience of The Biochemistry Laboratory of The Mohammed VI University Hospital of Oujda
  • Verification of the analytical performance of the serum CA 125 assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda

Nisma Douzi 1, 2, *, Amina Himri 1, 2, Imad-Eddine El khamlichi 1, 2, Oussama Grari 1, 2, Soufiane Beyyoudh 1, 2, Sabah Mokhtari 1, 2, Dounia El Moujtahide 1, 2, El-houcine Sebbar 1, 2 and Mohammed Choukri 1, 2

1 Mohammed First University, Faculty of Medicine and Pharmacy of Oujda, Morocco.
2 Biochemistry laboratory of Mohammed VI University Hospital, Oujda, Morocco.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 26(02), 230–238.
Article DOI: 10.30574/gscbps.2024.26.2.0067
DOI url: https://doi.org/10.30574/gscbps.2024.26.2.0067
Received on 06 January 2024; revised on 20 February 2024; accepted on 23 February 2024
The aim of our work was to evaluate the analytical performance of CA 125 determination by a two-step immunoassay using microparticle chemiluminescence immunoassay (CMIA) technology, in accordance with the Scope A criteria of the guide of the verification/validation of medical biology methods.
We evaluated the repeatability and the intermediate precision of the CA 125 assay.The results obtained are very satisfactory for the three levels (low, medium and high), both for intermediate fidelity, with coefficients of variation (CV) of 2.68%, 1.62% and 2.11% respectively, and for repeatability, with coefficients of variation of CV1 = 2.17%, CV2 = 2.04%, and CV3 = 1.38% respectively.
The results obtained made it possible to verify the method's performance and compare it with the analytical objectives set in order to meet the regulatory and normative requirements set by the supplier and learned societies.
The achieved results facilitated the verification of the method's performance and its comparison with the analytical objectives established, aligning with regulatory and normative requirements outlined by the supplier and relevant professional learned societies.
CA125; Verification; Repeatability; Reproducibility; Alinity ci
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2024-…

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Nisma Douzi, Amina Himri, Imad-Eddine El khamlichi, Oussama Grari, Soufiane Beyyoudh, Sabah Mokhtari, Dounia El Moujtahide, El-houcine Sebbar and Mohammed Choukri. Verification of the analytical performance of the serum CA 125 assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda. GSC Biological and Pharmaceutical Sciences, 2024, 26(2), 230-238. Article DOI: https://doi.org/10.30574/gscbps.2024.26.2.0067


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