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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

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Verification of the analytical performance of the serum anti-thyroperoxidase antibody assay on the Abbott Alinity ci®: Experience from the Biochemistry Laboratory of the Mohammed VI University Hospital of Oujda

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  • Verification of The Analytical Performance of The Serum Anti-thyroperoxidase Antibody Assay On The Abbott Alinity Ci®: Experience From The Biochemistry Laboratory of The Mohammed VI University Hospital of Oujda
  • Verification of the analytical performance of the serum anti-thyroperoxidase antibody assay on the Abbott Alinity ci®: Experience from the Biochemistry Laboratory of the Mohammed VI University Hospital of Oujda

Kaoutar Jamal 1, 2, *, Oumaima Kharkhach 1, 2, Sara Moulay Rchid 1, 2, Imane Douichi 1, 2, Dounia El Moujtahide 1, 2, El-Houcine Sebbar 1, 2 and Mohammed Choukri 1, 2

1 Mohammed First University, Faculty of Medicine and Pharmacy of Oujda, Morocco.
2 Biochemistry laboratory of Mohammed VI University Hospital, Oujda, Morocco.
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 30(02), 261-268.
Article DOI: 10.30574/gscbps.2025.30.2.0067
DOI url: https://doi.org/10.30574/gscbps.2025.30.2.0067
Received on 08 January 2025; revised on 15 February 2025; acceapted on 18 February 2025
The objective of this study was to evaluate the analytical performance of the measurement of anti-thyroperoxidase antibodies (anti-TPO antibodies) in human serum and plasma, using chemiluminescent microparticle immunoassay (CMIA), in accordance with Domain A criteria of the medical biology method verification/validation guide.
The results of the anti-TPO antibody serum assays show good repeatability for the three levels (1: low, 2: medium, and 3: high), with respective coefficients of variation (CV) of 1.67%, 1.97%, and 1.17%. Similarly, intermediate precision is considered satisfactory, with CV of 1.90% for level 1, 1.96% for level 2, and 1.38% for level 3. Comparison with the reference CV defined by the RICOS (Reference Institute for Clinical and Healthcare Standards) confirms the reliability and compliance of the results.
The results allowed us to verify the performance of the light chain Lambda assay method and compare it with the analytical objectives set in the accreditation process in which our laboratory is engaged
Anti-thyroperoxidase antibody assay; Analytical performance; Repeatability; Reproducibility; Coefficient of variation; Alinity ci® analyzer
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2025-…

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Kaoutar Jamal, Oumaima Kharkhach, Sara Moulay Rchid, Imane Douichi, Dounia El Moujtahide, El-Houcine Sebbar and Mohammed Choukri. Verification of the analytical performance of the serum anti-thyroperoxidase antibody assay on the Abbott Alinity ci®: Experience from the Biochemistry Laboratory of the Mohammed VI University Hospital of Oujda. GSC Biological and Pharmaceutical Sciences, 2025, 30(2), 261-268. Article DOI: https://doi.org/10.30574/gscbps.2025.30.2.0067


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