Tangeretin-a special polymethoxyflavones: An insight into its pharmacological and therapeutic effects on diabetes

With global diabetes complication growing rapidly at an alarming rate each year, there is an increasing need to find suitable therapeutics for its management, regulation, and treatment which is cost-effective, safe, and naturally available. Continued dependence only on the available synthetic drug is not a solution. Therefore, there is a need to find suitable natural adjuncts to help manage diabetes. Flavonoids are a class of compounds that have been utilized for therapeutic purposes for generations due to their wide and varied pharmacological properties. One such important naturally available flavonoid is tangeretin belonging to a special class of methylated flavonoids found mostly only in citrus fruits. It is reported to possess a lot of pharmaceutic activities, and thus in this brief review, we elucidate its specific importance in the attenuation of diabetic and diabetes-related complications to get a better understanding of its physiological mechanism of action in the context relating to diabetes.