Study the concentrations of Leptin, adiponectin and some parameters in women with polycystic ovaries syndrome

So this investigation was aimed to estimate concentrations of Leptin, adiponectin and some parameters in women with polycystic ovaries syndrome. From June to the end of February 2024, this investigation was carried out in the Teaching Azadi Hospital's laboratories. Eighty married women between the ages of 18-30 year provided blood serum samples for the study. Two groups were established from these samples, which are as follows: Control group: During the follicular phase of the menstrual cycle, thirty blood samples from healthy women were taken.  Patient group: During the follicular phase, 50 PCOS women had their blood samples taken. The results showed that LH concentration in serum of PCOS patients (8.74± 0.62) demonstrated significant (P <0.05) increase compared with healthy women (6.14± 0.37). The concentration of FSH demonstrated significant (P <0.05) reduced in PCOS patients (3.64 ± 1.08) compared with healthy women (8.29 ± 0.41). testosterone concentration in serum of PCOS patients (0.78± 0.39) demonstrated significant (P <0.05) increase compared with healthy women (0.36± 0.11). The concentration of IGF-1R demonstrated significant (P <0.05) elevated in PCOS patients (29.02 ± 5.67) compared with healthy women (17.42 ± 2.85). Adiponectin concentration in serum of PCOS patients (2.26± 0.19) demonstrated significant (P <0.05) reduced compared with healthy women (5.18 ± 0.24). the concentration of Leptin demonstrated significant (P <0.05) increase in PCOS patients (29.15 ± 3.47) compared with healthy women (8.27 ± 0.81). Significantly lower levels of adiponectin and higher levels of leptin and IGF-1R are linked to PCOS. These results call for additional research on the roles played by leptin, IGF-1R, and adiponectin in the pathophysiology of PCOS.