Sensing metabolomics landscape unfold molecular connectivity between mental illness and drug abuse

Environmental threats to mental equity have recently gained much attention in the sphere of public and curative health due to their toll on the individual, families, the public, and their economic sphere. Mental health or soundness of mind is important at every stage of life from childhood and adolescence through adulthood to protect the brain from environmental stress. What makes mental health unlike genetic rare disorders is that there is no known single cause for this rising public health issue because it arises from multiple factors. These factors include early adverse life experiences, such as trauma or a history of abuse either because of child abuse, sexual assault or seeing any form of violence, experiences related to other ongoing (chronic) medical conditions, such as cancer or diabetes, biological factors or chemical exposure resulting in hormonal imbalances in the brain, and to a large extent having feelings of loneliness or isolation leading to suicidal action. Furthermore, the increase in mental health and its accompanying conditions depend on environmental with or without behavioral changes due to genetic stability may be associated with drug, alcohol, or substance abuse which is associated with the brain reward circuit which may need to compromise the neural circuit over a wide range of stressors on the human body interacting with the sequential neuronal cell cascade. Although humoral networking is associated with socio-behavioral change, work through family, religious, organizational engagement, and community support play major roles in its solution and management, it is consensually accepted that defining key determinants underlying molecular network altering by epigenetic and genetic factors have promise in empowering future systematic health and personal care including surveillance, prevention, treatment, and monitoring process. In the modern global and urbanization era, emerging new biomedical technological advances such as epigenetic tools, genomics editing, human genomics study utilizing sequencing technology, and reverse genetic resources from worm to animal models have enabled us to take a closer look at mechanisms that could be involved in mental illness and drug abuse or addiction using a pattern of metabolomics and its connectivity reflecting the interplay between mental illness and drug abuse and/or addiction. This paper describes a molecular-driven surveillance platform as a part of the power of prevention to care of populational health which could be beneficial by predicting risk and unfolding the impact of daily lifestyle on human behavior such as food intake, alcohol intoxication, and its outcome likely the effect of metabolism on mental illness and drug abuse. Interaction between environmental cues to neural circuits which may interplay with metabolic networks as well as potential risk resulting in various forms of phenotypic complications and behavioral alteration might be detectable using multi-omics platforms.