Role of Cannabis sativa on wound healing: An update

Wound healing is one of the most complex and essential treatments in the human body and still remains a challenge in the healthcare system. Hemp-based materials are regarded as important components of wound dressings. Cannabidiol (CBD) and cannabis-based therapies may protect against oxidative stress, potentially reducing inflammation and cell damage in the chronic wound microenvironment and the surrounding tissues. Cannabis oil stands out in the realm of wound care due to its unique combination of antimicrobial, anti-inflammatory, and antioxidant properties. Cannabis oil offers a holistic approach to managing inflammation, minimizing systemic exposure, and promoting overall skin health and regeneration. Wound dressings are essential for maintaining a moist environment and protecting the wound; however, they can benefit from the addition of cannabis oil, which can enhance their effectiveness by providing added anti-inflammatory and antimicrobial support. In vitro studies have offered a variety of targets in which cannabis containing compounds may influence wound healing.  Overall, these studies suggest a positive effect on wound healing by cannabinoids.  CBD oil can be used as a remedy for skin lesions. Hydrogel composite prepared from bio-based materials is therefore considered as a promising route. However, further clinical research is needed to fully understand the mechanisms involved and to optimize the therapeutic applications of cannabis oil in wound care.  Further research is needed to understand the full spectrum of side effects of topical cannabinoids.