Biochemistry Department, Niger Delta University, Bayelsa State, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 08(02), 053–058.
Article DOI: 10.30574/gscbps.2019.8.2.0064
Received on 12 April 2019; revised on 24 July 2019; accepted on 29 July 2019
This study is designed to investigate the inhibitory effect of Celosia trigyna against xanthine oxidase. Total flavonoid, phenol, vitamin C were evaluated using standard methods and inhibitory activity of Celosia trigyna extract on xanthine oxidase (XO) activity in vitro and chelating properties of extract against Iron (II) were also carried out. The results showed that the extract contained high content of flavonoids, phenolic acid and vitamin C that are beneficial to health. The extract inhibited XO in a dose-dependent manner. The extract also chelated Fe2+ in a dose-dependent manner. Celosia trigyna extract could be a promising nutraceutical for preventing and managing hyperuricaemia due to its ability to inhibit XO; this activity is attributed to the combined effect of its phytochemicals and chelating properties.
Celosia trigyna; Total flavonoid; Vitamin C; Phenolic acid; Xanthine oxidase
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Eboh AS, Arhoghro EM, Frank-Oputu A, Wodu E, Adah OG and Uwuma BA. Phytochemicals and chelating properties in extract of Celosia trigyna inhibits xanthine oxidase in vitro. GSC Biological and Pharmaceutical Sciences, 2019, 8(2), 053-058. Article DOI: https://doi.org/10.30574/gscbps.2019.8.2.0064