1 IV Year B.Pharmacy, Ratnam Institute of Pharmacy, Pidathapolur (V &P), SPSR Nellore – 524 346.
2 Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V &P), SPSR Nellore – 524 346.
3 Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur (V &P), SPSR Nellore – 524 346.
Bandela Abhilash : https://orcid.org/0009-0009-8598-5681
Yerikala Ramesh : https://orcid.org/0000-0002-8331-8190
Research Article
GSC Biological and Pharmaceutical Sciences, 2025, 33(01), 364–376.
Article DOI: 10.30574/gscbps.2025.33.1.0418
Received on 20 September 2025; revised on 28 October 2025; accepted on 31 October 2025
Detecting diseases at an early stage is crucial for improving survival rates, ensuring timely treatment, and minimizing healthcare burdens. Traditional diagnostic techniques, such as imaging and biochemical testing, often identify diseases only after symptoms become evident, which reduces their effectiveness in early diagnosis. In contrast, novel biomarkers have emerged as promising tools that enable detection of pathological alterations at the molecular and cellular level long before clinical signs appear.
Biomarkers serve as quantifiable indicators of physiological or pathological processes and therapeutic responses. Advances in molecular biology, genomics, proteomics, and metabolomics have expanded the discovery of novel biomarkers, including circulating tumor DNA (CTDNA), microRNAs, exosomes, and specific metabolic patterns. These innovative indicators show great potential for the early identification of cancers, cardiovascular conditions, neurodegenerative diseases, and infectious disorders.
Beyond early detection, novel biomarkers assist in disease risk evaluation, prognosis, and monitoring of treatment efficacy. Their growing use aligns with the principles of personalized and precision medicine, enabling tailored diagnostic and therapeutic strategies for individual patients.
Nevertheless, the implementation of these biomarkers in clinical settings faces challenges, such as lack of validation, standardization issues, and regulatory constraints. Ongoing research and technological progress are essential to overcome these barriers and fully realize the potential of novel biomarkers in transforming early disease detection and enhancing global health outcomes.
Novel Biomarkers; Early Diagnosis; Molecular Detection; Precision Medicine; Disease Prognosis
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Bandela Abhilash, Yerikala Ramesh, Venugopalaiah Penabaka and Yadala Prapurna Chandra. Novel biomarkers in early disease detection. GSC Biological and Pharmaceutical Sciences, 2025, 33(1), 364-376. Article DOI: https://doi.org/10.30574/gscbps.2025.33.1.0418