Formulation and evaluation of posaconazole Emulgel: A novel topical drug delivery

The goal of this study is to create a Posaconazole emu gel that will enable the medication to permeate the skin more deeply than current preparations. Posaconazole, a triazole antifungal medication, is used to prevent severe fungal infections. When administered orally, this medication absorbs slowly. Topical pharmaceutical delivery is preferred as a therapy method because it prevents the drug's first-pass metabolism. Posaconazole emu gel is prepared using the gelling agent carbopol 934. Furthermore, oleic acid is used as an emulsifier for the oil phase, while tween 80 is used as an emulsifier for the aqueous phase, propylene glycol and Transcutol P serves as a co-surfactant and Transcutol in this formulation has used for its ability to enhance anti- fungal property, and methyl paraben and propyl paraben are employed as preservatives. TEA (Triethanolamine) was Added to adjust the pH of the emu gel to 6-6.5. All of the prepared emulgels had satisfactory physical properties. The batch F6 of the formulation demonstrates improved drug release compared to the other formulations.