Formulation and evaluation of lovastatin tablets by using liquid solid compact technique

Lovastatin is a poorly soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. There are several techniques to enhance the dissolution of poorly soluble drugs. Among them, the technique of liquid-solid compacts is one of the promising techniques towards such a novel aim. Hence the objective of the present work is to formulate & evaluate tablets by liquid-solid compacts technique. The physicochemical characteristics of Lovastatin compacts such as FTIR Flow properties, Hardness, Friability, in vitro release, Release kinetics were evaluated. The FTIR Spectra revealed that there was no interaction between polymer and Lovastatin. The in vitro performance of Lovastatin compacts showed control release depends on the polymer concentrations. The diffusion exponent (n) of Korsmeyer-Peppas model was found to be non-Fickian. The results showed that liquid-solid compacts had demonstrated significantly higher drug release rates than those of conventionally made. This was due to an increase in wetting properties and surface of drug available for dissolution.