Evaluating the efficacy of topical Centella asiatica in accelerating burn healing in animal models: A systematic review

Centella asiatica (CA), a medicinal plant with historical use in traditional medicine, is rich in bioactive compounds like asiaticoside, madecassoside, and asiatic acid, which are known for their anti-inflammatory, antioxidant, and collagen-boosting properties. These compounds are especially beneficial in addressing the complexities of burn healing, which involves a balance between inflammation, tissue regeneration, and scarring. The review covers experimental studies focusing in CA in burn animal model from 2014 to 2024, focusing on various outcomes in the aspects of gross, histology, and markers. Results indicate that CA significantly accelerates healing by enhancing tissue repair processes and improving wound quality while reducing scar formation. However, variations in experimental methods, including differences in burn induction, CA formulation, and outcome measurements, highlight a need for standardized research protocols. Findings suggest that CA holds promise as a low-cost, effective therapeutic option for burn treatment, particularly valuable in low-resource settings. This review underlines the importance of further clinical trials to confirm CA’s therapeutic potential, with the goal of developing accessible and effective treatments for burn injuries in humans.