Development of a Novel Herbal Balm using Mimosa pudica Leaf Extract for Headache and Migraine

The ethanolic leaf extract of Mimosa pudica L. was used to create a new herbal balm for the topical treatment of headaches and migraines. The plant's analgesic and anti-inflammatory qualities are among its traditional uses. The goal of the study was to create and assess a stable, semi-solid preparation that would be simple to use. After physicochemical constants and macroscopy were used to characterize the leaf material, a Soxhlet apparatus was used to extract the ethanol. A combination of waxes (beeswax, Vaseline), oil (castor oil), and additives (menthol, camphor, glycerine) was used to create three formulations (F1, F2, and F3). Evaluation studies revealed that the final optimized formulation (F3) was non-irritating, washable, and had good spreadability (18.6 g.cm/sec), as well as desirable organoleptic qualities. Key metabolites like flavonoids and tannins were found to be present by preliminary phytochemical investigation. Additionally, Formulation F3 showed considerable dose-dependent action in in vitro anti-inflammatory screening using the protein denaturation method, with a maximum protein denaturation inhibition of 63.63% at a dosage of 30 ppm, suggesting that it may be used to relieve pain. These findings support the produced Mimosa pudica herbal balm's stability and medicinal potential.