Development and formulation of Aloe vera emulgel

Aloe vera is most popular in treatment of dermatological disorder in case of burn, tan and wound healing. The study was designed for crude Aloe vera extract, development of oil in water (o/w) emulsion, preparation of gel base using Aloe vera extract and formulation of the emulgel for topical application. The formulation was prepared by using carbomer 940 as polymer and isopropyl alcohol as penetration enhancer. The pH and viscosity of the Aloe vera emulgel were noticed to be 6.8 and 750 centipoise (cps) respectively. The interaction study between phytochemicals and the excipients was carried out using Fourier transform infrared (FTIR) spectroscopy. UV spectrometric analysis of plant extract was carried out. Dynamic light scattering (DLS) was performed to determine the particle size distribution of oil globules in emulsion. Mean particle size (oil globules) was observed to be 481 nm. Zeta potential and polydispersity index (PDI) was recorded to be -13.2 mV and 0.6 respectively.