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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

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Biologically relevant surrogates of coumarins: 2-phenyl H-isophosphinoline 2-oxides with antibacterial activity

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  • Biologically Relevant Surrogates of Coumarins: 2-phenyl H-isophosphinoline 2-oxides With Antibacterial Activity
  • Biologically relevant surrogates of coumarins: 2-phenyl H-isophosphinoline 2-oxides with antibacterial activity

Mina Hariri 1, 2, Fatemeh Darvish 2, Karen-Pacelye Mengue Me Ndong 1, 3, Rachida Babouri 1, Jacques Lebibi 3, Gabin Mwande-Maguene 3, Alexander R Burilov 4, Patricia Licznar-Fajardo 5, Jean-Luc Pirat 1, *, Tahar Ayad 1, * and David Virieux 1, *

1 ICGM, Univ. Montpellier, ENSCM, CNRS, Montpellier, France.
2 Department of Chemistry, K. N. Toosi University of Technology, P.O. Box, 15875-4416 Tehran, Iran.
3 UniversitΓ© des Sciences et Techniques de Masuku, Franceville, Gabon.
4 Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, Kazan 420088, Russian Federation.
5 Hydro Sciences Montpellier, Univ Montpellier, CNRS, IRD, CHU Montpellier, Montpellier, France.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 16(02), 283-296.
Article DOI: 10.30574/gscbps.2021.16.2.0252
DOI url: https://doi.org/10.30574/gscbps.2021.16.2.0252
Received on 23 August 2021; revised on 26 August 2021; accepted on 28 August 2021
 
The present study aims to investigate the in vitro antibacterial activities of several isophosphinoline-2-oxides that can be perceived as combined bio isosteres of coumarins and flavonoids. More specifically, antibacterial activity was evaluated against four bacterial strains, including the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and the Gram-positive bacteria Staphylococcus aureus and Enterococcus faecalis by using disk diffusion assay. Notably, isophosphinoline-2-oxide compounds showed promising and highly selective antimicrobial activity against S. aureus.
 
Isophosphinoline-2-oxides; Phosphacoumarins; Synthesis; Antibacterial activities
 
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2021-…

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Mina Hariri, Fatemeh Darvish, Karen-Pacelye Mengue Me Ndong, Rachida Babouri, Jacques Lebibi, Gabin Mwande-Maguene, Alexander R Burilov, Patricia Licznar-Fajardo, Jean-Luc Pirat, Tahar Ayad and David Virieux. Biologically relevant surrogates of coumarins: 2-phenyl H-isophosphinoline 2-oxides with antibacterial activity. GSC Biological and Pharmaceutical Sciences, 2021, 16(2), 283-296. Article DOI: https://doi.org/10.30574/gscbps.2021.16.2.0252


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