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Research and review articles are invited for publication in September 2026 - Vol. 36, Issue 3 

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Analytical method validation for metformin quantification in dissolution medium

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  • Analytical method validation for metformin quantification in dissolution medium

Bogantes-Molina Joselyn 1, Madrigal-Redondo German Leonardo 1, 2, *, Berrocal-Barrantes Lorena 1, 2, Chavarría-Rojas Marianela 1, Acuña-Amador Daniel Alejandro 1, 2 and Vargas-Zúñiga Rolando 1, 2

1 Pharmacy School, Universidad Latina of Costa Rica, San José, Costa Rica.
2 Faculty of Pharmacy, University of Costa Rica, San José, Costa Rica.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2019, 07(02), 043–051.
Article DOI: 10.30574/gscbps.2019.7.2.0049
DOI url: https://doi.org/10.30574/gscbps.2019.7.2.0049
Received on 25 March 2019; revised on 16 April 2019; accepted on 20 April 2019
 
Metformin hydrochloride is a hypoglycemic agent used for type II Diabetes Mellitus treatment, and one of the most used to manage it. The objective of the present work was the development and validation of an analytical method to quantify metformin hydrochloride in the dissolution medium by UV spectrophotometry. Linearity and range, accuracy and precision were the validation process parameters. Validation process results showed the analytical method was easy, quick, secure and, furthermore, a linear, accurate and precise method in the studied concentrations range.  Therefore, it is a reliable analytical method.
Metformin hydrochloride; Validation; Analytical method; Quantification; Dissolution; Spectrophotometry
 
https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2019-…

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Bogantes-Molina Joselyn, Madrigal-Redondo German Leonardo, Berrocal-Barrantes Lorena, Chavarría-Rojas Marianela, Acuña-Amador Daniel Alejandro and Vargas-Zúñiga Rolando. Analytical method validation for metformin quantification in dissolution medium. GSC Biological and Pharmaceutical Sciences, 2019, 7(2), 043-051. Article DOI: https://doi.org/10.30574/gscbps.2019.7.2.0049


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